Spermatocyte responses in vitro to induced DNA damage.

  title={Spermatocyte responses in vitro to induced DNA damage.},
  author={Shannon Matulis and Mary Ann Handel},
  journal={Molecular reproduction and development},
  volume={73 8},
Spermatocytes normally sustain many meiotically induced double-strand DNA breaks (DSBs) early in meiotic prophase; in autosomal chromatin, these are repaired by initiation of meiotic homologous-recombination processes. Little is known about how spermatocytes respond to environmentally induced DNA damage after recombination-related DSBs have been repaired. The experiments described here tested the hypothesis that, even though actively completing meiotic recombination, pachytene spermatocytes… CONTINUE READING

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