Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

@article{Chen2016SpermTC,
  title={Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder},
  author={Q. Chen and M. Yan and Zhonghong Cao and X. Li and Yunfang Zhang and Junchao Shi and G. Feng and Hongying Peng and Xudong Zhang and Y. Zhang and Jingjing Qian and E. Duan and Q. Zhai and Q. Zhou},
  journal={Science},
  year={2016},
  volume={351},
  pages={397 - 400}
}
Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen et al. injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and… Expand
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  • 11
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  • C. Schubert
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  • Biology of reproduction
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  • PDF
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2
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4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
  • 382
  • PDF
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals
  • 273
  • PDF
RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse.
  • 231
Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance
  • W. Yan
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • 2014
  • 64
...
1
2
3
4
...