Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

@article{Chen2016SpermTC,
  title={Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder},
  author={Qi Chen and Menghong Yan and Zhonghong Cao and Xin Li and Yunfang Zhang and Junchao Shi and Guihai Feng and Hongying Peng and Xudong Zhang and Ying Zhang and Jingjing Qian and Enkui Duan and Qiwei Zhai and Qi Zhou},
  journal={Science},
  year={2016},
  volume={351},
  pages={397 - 400}
}
Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen et al. injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and… 
Sperm tsRNAs and acquired metabolic disorders.
TLDR
Current knowledge of a father's influence on metabolic disorders in subsequent generations is provided and the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission are discussed.
Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs
TLDR
It is shown that offspring of fathers with inflammation exhibit metabolic disorders including glucose intolerance and obesity, and that Ang-mediated biogenesis of 5′-tsRNAs in sperm contributes to paternal inflammation-induced metabolic disorders in offspring.
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
TLDR
It is reported that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring and that DnMT2-mediated m5C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information.
Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information
TLDR
The mechanism of sperm small RNA remodeling during post-testicular maturation in the epididymis, and the potential role of this reprograming in intergenerational epigenetic inheritance are explored.
Sperm RNA code programmes the metabolic health of offspring
TLDR
How the RNA code in sperm might be decoded in the early embryo and transformed molecular signals to influence embryonic development and offspring phenotypes is discussed.
Male reproductive health and intergenerational metabolic responses from a small RNA perspective
TLDR
A theoretical framework for an overlap of these aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses is presented by exploring the advances in the understanding of the roles of sncRNA in spermatogenesis and offspring development.
Role of miRNA in the Transmission of Metabolic Diseases Associated With Paternal Diet-Induced Obesity
The concept of Developmental Origins of Health and Diseases (DOHaD) recognizes that an unfavorable maternal environment alters the developmental trajectory of the fetus and can lead to long-term risk
The influence of paternal diet on sncRNA-mediated epigenetic inheritance
TLDR
The current literature suggests that sncRNAs mediate paternal intergenerational epigenetic inheritance and thus has a direct functional importance, as well as possess biomarker potential, for metabolic diseases.
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