Sperm shape abnormality and urine mutagenicity in mice treated with niclosamide.

@article{Vega1988SpermSA,
  title={Sperm shape abnormality and urine mutagenicity in mice treated with niclosamide.},
  author={S G Vega and Patricia Guzm{\'a}n and Luis Gonz{\'a}lez Garc{\'i}a and Javier Espinosa and C Cortinas de Nava},
  journal={Mutation research},
  year={1988},
  volume={204 2},
  pages={269-76}
}
Niclosamide, a widely used anthelmintic drug in underdeveloped countries, is known to be mutagenic in the Salmonella typhimurium microsomal test system. The urine obtained from mice treated with niclosamide is mutagenic in the TA98 and TA1538 strains. Its effects on mouse-sperm morphology were evaluated in CD1 and (BALB/cJ x DBA/2J) F1 mice after 5 daily oral niclosamide doses of either 60, 80, 100 or 120 mg/kg. A statistically significant increase in abnormal sperm morphology was detected in… CONTINUE READING