Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association.

@article{Webb2008SpermCA,
  title={Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association.},
  author={Adam J Webb and Ingrid L. Berg and Alec John Jeffreys},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 30},
  pages={10471-6}
}
Population diversity data have recently provided profound, albeit inferential, insights into meiotic recombination across the human genome, revealing a landscape dominated by thousands of cross-over hotspots. However, very few of these putative hotspots have been directly analyzed for cross-over activity. We now describe a search for very active hotspots, by using extreme breakdown of marker association as a guide for high-resolution sperm cross-over analysis. This strategy has led to the… CONTINUE READING