Sperm chromatin damage associated with male smoking.

  title={Sperm chromatin damage associated with male smoking.},
  author={RM. Potts and Clinton Newbury and Glenn Smith and LidiaJ. Notarianni and T M Jefferies},
  journal={Mutation research},
  volume={423 1-2},
Cigarette smoke is a rich source of mutagens and carcinogens; thus, we have investigated the effects of male smoking on the DNA of human sperm. This was performed using the sperm chromatin structure assay (SCSA), which measures the sensitivity of sperm DNA to acid induced denaturation, and the terminal deoxynucleotidyl transferase assay (TdTA), which measures DNA strand breaks by addition of the biotinylated nucleotide dUTP to 3'-OH ends of DNA, sites of DNA breakage, using the enzyme terminal… CONTINUE READING
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