Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma.

@article{Garg2008SpermassociatedA9,
  title={Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma.},
  author={Manoj Garg and Deepika Kanojia and Aashima Khosla and Namrata Dudha and Satish Sati and Dipak Chaurasiya and Nirmala Jagadish and Amlesh Seth and Rajive Kumar and Samir Gupta and Anju Gupta and Nirmal K. Lohiya and Anil Suri},
  journal={Cancer research},
  year={2008},
  volume={68 20},
  pages={
          8240-8
        }
}
Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiation and chemotherapy. Current therapies for RCC patients are inefficient due to the lack of diagnostic and therapeutic markers. Our recent studies have suggested an association of sperm-associated antigen 9 (SPAG9) with ovarian carcinomas. In the present study, we investigated the clinical relevance of SPAG9 in RCC patients. RT-PCR analysis showed expression of SPAG9 transcript in RCC tissues and RCC cell lines. In… 
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Sperm-associated antigen 9 is a novel biomarker for colorectal cancer and is involved in tumor growth and tumorigenicity.

Sperm associated antigen 9 (SPAG9) a promising therapeutic target of ovarian carcinoma

In vivo ovarian cancer xenograft studies showed that ablation of SPAG9 resulted in significant reduction in tumor growth, and in vitro assays revealed therapeutic potential of S PAG9 in ovarian cancer.

Sperm-associated antigen 9 is upregulated in hepatocellular carcinoma tissue and enhances QGY cell proliferation and invasion in vitro.

The results of the present study suggested that SPAG9 was upregulated in HCC and may serve an important function in cancer cell proliferation, differentiation and invasion.

Sperm Associated Antigen 9 Plays an Important Role in Bladder Transitional Cell Carcinoma

The data in clinical specimens indicated that SPAG9 is potential biomarker and therapeutic target for bladder TCC, and gene silencing resulted in reduction in cellular growth, and migration and invasion ability of cancer cells in vitro.

Ror2, a Developmentally Regulated Kinase, Is Associated With Tumor Growth, Apoptosis, Migration, and Invasion in Renal Cell Carcinoma.

Analysis of receptor tyrosine kinase-like orphan receptor 2 (Ror2), a new tumor-associated kinase, in RCC primary tumors and cell lines suggests a novel pathway of tumor-promoting activity by Ror2 within renal carcinomas, with significant implications for unraveling the tumorigenesis of RCC.

SPAG9 expression is increased in human prostate cancer and promotes cell motility, invasion and angiogenesis in vitro.

Tissue microarray and immunohistochemistry data indicate that SPAG9 expression is significantly increased in PCa and it may be involved in the process of prostate cancer cell motility, migration and angiogenesis.

Overexpression of SPAG9 correlates with poor prognosis and tumor progression in hepatocellular carcinoma

SPAG9 is overexpressed in human HCC and serves as a prognostic marker that contributes to cancer cell growth through regulation of cyclin proteins and could increase cell apoptosis.

Sperm-associated antigen 9: a novel diagnostic marker for thyroid cancer.

Findings support a potential role for SPAG9 as diagnostic biomarker as well as a possible therapeutic target in thyroid cancer treatment, and small interfering RNA-mediated knockdown of SPAg9 expression in thyroidcancer cell significantly reduced cellular growth and colony formation.

SPAG9 promotes prostate cancer growth and metastasis

In conclusion, this is the first study to provide evidence that SPAG9 promotes bone metastasis of prostate cancer, and SPAg9 is a promising target to prevent or treat bone metastases of prostatecancer.

SPAG 9 controls the cell motility , invasion and angiogenesis of human osteosarcoma cells

The results of the present study indicated that SPAG9 may be an important regulator in osteosarcoma and may be involved in metastasis, and may also be a promising target for the treatment of metastatic OS.
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