Sperm aneuploidy in fathers of Klinefelter's syndrome offspring assessed by multicolour fluorescent in situ hybridization using probes for chromosomes 6, 13, 18, 21, 22, X and Y.

@article{Arnedo2006SpermAI,
  title={Sperm aneuploidy in fathers of Klinefelter's syndrome offspring assessed by multicolour fluorescent in situ hybridization using probes for chromosomes 6, 13, 18, 21, 22, X and Y.},
  author={N{\'u}ria Arnedo and Cristina Templado and Yolanda S{\'a}nchez-Blanque and Osvaldo Rajmil and Carme Nogu{\'e}s},
  journal={Human reproduction},
  year={2006},
  volume={21 2},
  pages={524-8}
}
BACKGROUND It is still unclear if a recurrence risk would exist in fathers of an aneuploid offspring of paternal origin. We have studied disomy frequencies in spermatozoa from fathers having Klinefelter syndrome (KS) offspring or miscarriages. The effect of paternal age on sperm disomy percentages is also analysed. METHODS Parental origin of 17 KS patients was carried out by amplification of X chromosome polymorphisms. Spermatozoa from their fathers were studied by multicolour fluorescent in… CONTINUE READING

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