Sperm aneuploidy and meiotic sex chromosome configurations in an infertile XYY male.

@article{Wong2008SpermAA,
  title={Sperm aneuploidy and meiotic sex chromosome configurations in an infertile XYY male.},
  author={Edgar Chan Wong and Kyle A Ferguson and Victor Chow and Sai Ma},
  journal={Human reproduction},
  year={2008},
  volume={23 2},
  pages={374-8}
}
BACKGROUND There is little information regarding the behaviour of the extra Y chromosome during meiosis I in men with 47,XYY karyotypes and the segregation of the sex chromosomes in sperm. We applied immunofluorescent and FISH techniques to study the relationship between the sex chromosome configuration in meiotic germ cells and the segregation pattern in sperm, both isolated from semen samples of a 47,XYY infertile man. METHODS The sex chromosome configuration of pachytene germ cells was… CONTINUE READING