Sperm activation: role of reactive oxygen species and kinases.

@article{Lamirande2008SpermAR,
  title={Sperm activation: role of reactive oxygen species and kinases.},
  author={Eve de Lamirande and Cristian O'Flaherty},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1784 1},
  pages={
          106-15
        }
}
Reactive oxygen species (ROS), such as the superoxide anion (O(2)(-*)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO*), when generated at low and controlled levels, act as second messengers. ROS regulate sperm capacitation, which is the complex series of changes allowing spermatozoa to bind to the zona pellucida surrounding the oocyte, induce the acrosome reaction (exocytotic event by which proteolytic enzymes are released) and fertilize the oocyte. Capacitating spermatozoa produce… CONTINUE READING

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