Sperm-Mediated Gene Transfer: Concepts and Controversies

  title={Sperm-Mediated Gene Transfer: Concepts and Controversies},
  author={Kevin R. Smith and Pablo Bermejo-Alvarez and Sebastian Canovas and Tiago Veiras Collares and Odir Antonio Dellagostin and Jo{\~a}o carlos Deschamps and Vinicius Farias Campos and Ra{\'u}l Fern{\'a}ndez-Gonz{\'a}lez and C. Calleja de Frutos and Joaqu{\'i}n Gadea and Francisco A Garc{\'i}a-V{\'a}zquez and Nasser Ghanem and Michael Gurevich and Alfonso Guti{\'e}rrez-Ad{\'a}n and Eliane Harel-Markowitz and Michael Hoelker and Ann Anderson Kiessling and Ricardo Laguna and Carlos Frederico Ceccon Lanes and Luis Fernando Fernandes Marins and Alberto Miranda and John Parrington and Miriam P{\'e}rez-Crespo and Karl Schellander and Ilaria Sciamanna and Fabiana K{\"o}mmling Seixas and M. Shemesh and Laurence S. Shore and Corrado Spadafora and Yehuda Stram and Dawit Tesfaye and Wei Shen and Xiaofeng Sun and Yidong Niu},
Description: Sperm-mediated gene transfer (SMGT) represents a novel set of technologies for animal (or in the future, human) genetic modification using the sperm as a vector, as opposed to more traditional established routes such as fertilized eggs or embryonic stem cells. Studies of sperm-mediated gene transfer (SMGT) indicate that sperm cells possess the ability to be utilized as carriers of exogenous genetic sequences, offering the potential of a novel cost-effective route for germline… CONTINUE READING


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