Sperm DNA integrity in cancer patients before and after cytotoxic treatment.

@article{Smit2010SpermDI,
  title={Sperm DNA integrity in cancer patients before and after cytotoxic treatment.},
  author={Marij Smit and Niels J van Casteren and Mark F. Wildhagen and Johannes C. Romijn and Gert R. Dohle},
  journal={Human reproduction},
  year={2010},
  volume={25 8},
  pages={1877-83}
}
BACKGROUND We assessed sperm DNA fragmentation index (DFI) in cancer patients before and after treatment to evaluate if sperm DNA integrity is compromised by cancer itself or its treatment. METHODS In a prospective study, DFI was assessed in 127 patients diagnosed with testicular germ cell tumours (TGCT), Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL) and various malignancies. The severity of cancer and tumour markers at diagnosis was recorded. Follow-up DFI after treatment was… CONTINUE READING

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