Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility

@article{Shamsi2011SpermDI,
  title={Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility},
  author={Monis Bilal Shamsi and Syed Nazar Imam and Rima Dada},
  journal={Journal of Assisted Reproduction and Genetics},
  year={2011},
  volume={28},
  pages={1073-1085}
}
Sperm is not a simple carrier of paternal genetic information but its role extends clearly beyond fertilization. Integrity of sperm genome is an essential pre-requisite for birth of healthy offspring and evaluation of sperm should entail DNA integrity analysis. DNA integrity analysis is a better diagnostic and prognostic marker of sperm reproductive potential. Conventional semen analysis emphasizes on sperm concentration, viability, motility and morphology and has been proven to be a poor… CONTINUE READING