Spent embryo culture medium metabolites are related to the in vitro attachment ability of blastocysts

@inproceedings{Dsouza2018SpentEC,
  title={Spent embryo culture medium metabolites are related to the in vitro attachment ability of blastocysts},
  author={Fiona D'souza and Shubhashree Uppangala and Gitanjali Asampille and Sujith Raj Salian and Guruprasad Kalthur and Riccardo Talevi and Hanudatta S Atreya and Satish Kumar Adiga},
  booktitle={Scientific Reports},
  year={2018}
}
The metabolomic profile of an embryo culture medium can aid in the advanced prediction of embryonic developmental potential and genetic integrity. But it is not known if this technology can be used to determine the in vitro potential of inner cell mass (ICM) in adherence and proliferation. Here, we investigated the developmental potential of mouse 2-cell embryos carrying cisplatin-induced DNA lesions (IDL), beyond blastocyst stage using ICM outgrowth assay. The genetic integrity of ICM cells… CONTINUE READING
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