Spegazzinine, a new inhibitor of mitochondrial oxidative phosphorylation.


The effects of spegazzinine, a dihydroindole alkaloid, on mitochondrial oxidative phosphorylation were studied. Spegazzinine inhibited coupled respiration and phosphorylation in rat liver mitochondria. The I50 was 120 microM. Uncouplers released the inhibition of coupled respiration. Arsenate-stimulated mitochondrial respiration was partially inhibited by… (More)