Speed coronavirus vaccine testing by deliberately infecting volunteers? Not so fast, some scientists warn

@article{Cohen2020SpeedCV,
  title={Speed coronavirus vaccine testing by deliberately infecting volunteers? Not so fast, some scientists warn},
  author={Jon Cohen},
  journal={Science},
  year={2020}
}
  • Jon Cohen
  • Published 31 March 2020
  • Medicine
  • Science
Latest Effective Measures to Combat COVID-19: A Review
TLDR
By synthesizing the scientific experience in fighting the COVID-19 epidemic, it is suggested the latest effective measures should be carried out concurrently from three aspects, so as to avoid making grim situation even worse.
Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies
Testing SARS-CoV-2 vaccine efficacy through deliberate natural viral exposure
Controlled COVID-19 Infection in Hospitals Could Achieve A Safer Exit Strategy in the Near-Term: Assessing Risks and Benefits
TLDR
It is postulate that controlled voluntary deliberate infection in a hospital setting and under continuous and close medical observation may offer a safer alternative compared to random en-masse exposure.
Coronavirus Human Infection Challenge Studies: Assessing Potential Benefits and Risks
TLDR
Several considerations that should inform systematic assessment of SARS-CoV-2 HCS are explored and interactions between public health policy and research priorities are highlighted, including situations in which research ethics assessments may need to strike a balance between competing considerations.
Efforts towards a COVID-19 vaccine.
  • H. Brüssow
  • Political Science
    Environmental microbiology
  • 2020
TLDR
An overview of vaccine candidates in development, including preclinical and clinical testing, and it also mentions some of the societal problems of vaccine acceptance.
Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development
TLDR
It is found that HCTs are likely to be most useful for vaccine candidates currently in preclinical stages of development, and that, while currently limited in their application, there are scenarios in which H CTs would be extremely beneficial.
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