Spectrum of the mu, delta- and kappa-binding sites in homogenates of rat brain.

@article{Gillan1982SpectrumOT,
  title={Spectrum of the mu, delta- and kappa-binding sites in homogenates of rat brain.},
  author={Maureen G C Gillan and Hans W. Kosterlitz},
  journal={British journal of pharmacology},
  year={1982},
  volume={77 3},
  pages={461-9}
}
1 In homogenates of rat brain, the binding characteristics of tritiated opiates and opioid peptides were examined and the relative capacities of mu-, delta- and kappa-binding sites of the opiate receptor determined by saturation analysis.2 In competition experiments, binding of the selective mu-ligand [(3)H]-[D-Ala(2),MePhe(4),Gly-ol(5)]enkephalin at the mu-site was displaced by [D-Ala(2),D-Leu(5)]enkephalin with rather low affinity (K(I) = 12.6 nM) and more readily by the ketazocine-like… CONTINUE READING

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