Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

  title={Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.},
  author={Fiona M. Platt and Carolyn D. Hurst and Claire Fraser Taylor and Walter Martin Gregory and Patricia M Harnden and Margaret A Knowles},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 19},
PURPOSE The phosphatidylinositol 3-kinase (PI3K) pathway can be activated by alterations affecting several pathway components. For rational application of targeted therapies, detailed understanding of tumor biology and approaches to predict efficacy in individual tumors are required. Our aim was to assess the frequency and distribution of pathway alterations in bladder cancer. EXPERIMENTAL DESIGN We examined the pathway components (PIK3CA, PTEN, TSC1, RHEB, and LKB1) and putative upstream… CONTINUE READING
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