Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV.

@article{Safi2003SpectrumOM,
  title={Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV.},
  author={Hassan Safi and Bobby J. Gormus and Peter J. Didier and James L. Blanchard and David L. Lakey and Louis N. Martin and Micheal Murphey-Corb and Ramakrishna Vankayalapati and Peter F. Barnes},
  journal={AIDS research and human retroviruses},
  year={2003},
  volume={19 7},
  pages={585-95}
}
To characterize the manifestations of coinfection with M. tuberculosis and SIV infection, we studied 12 SIV-infected rhesus monkeys, six of which were infected intrabronchially with a low dose of Mycobacterium tuberculosis H37Rv. In the six coinfected animals, M. tuberculosis antigen-stimulated lung and blood cells produced high concentrations of IFN-gamma but not IL-4 8-16 weeks after infection. Of the three coinfected animals with high levels of plasma viremia, two developed disseminated… CONTINUE READING