Spectrum of alpha-globin gene mutations among premarital Baluch couples in southeastern Iran

@inproceedings{MiriMoghaddam2015SpectrumOA,
  title={Spectrum of alpha-globin gene mutations among premarital Baluch couples in southeastern Iran},
  author={Ebrahim Miri-Moghaddam and Abass Nikravesh and Negin Gasemzadeh and Mahin Badaksh and Nahid Rakhshi},
  booktitle={International journal of hematology-oncology and stem cell research},
  year={2015}
}
BACKGROUND Alpha thalassemia (α-thal) is one of the most common hemoglobinopathies worldwide. The aim of this study was to investigate the spectrum of α-thal mutations among premarital Baluch couples in southeastern Iran. SUBJECTS AND METHODS We assessed 1215 individuals by multiplex gap polymerase chain reaction (gap-PCR) and amplification refractory mutation system (ARMS-PCR). RESULTS Of the 1215 participants with mean age of 23±5.7 years, 62.3% lived in urban areas, and the rate of… CONTINUE READING

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