Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice.

@article{Kakinuma2002SpectrumOZ,
  title={Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of heterozygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice.},
  author={Shizuko Kakinuma and Mayumi Nishimura and Syun-ichi Sasanuma and Kazuei Mita and Gen Suzuki and Yoshimoto Katsura and Toshihiko Sado and Yoshiya Shimada},
  journal={Radiation research},
  year={2002},
  volume={157 3},
  pages={331-40}
}
Ikaros (now known as Znfn1a1), a Krüppel-type zinc-finger transcription factor that plays a critical role in both lineage commitment and differentiation of lymphoid cells, has recently been shown to function as a tumor suppressor gene. We have previously reported a high frequency of LOH (approximately 50%) at the Znfn1a1 locus in radiation-induced T-cell lymphoma in susceptible B6C3F1 mice. The aim of the present study was to delineate the types of Znfn1a1 inactivation, with special reference… CONTINUE READING