Spectrum of Epstein-Barr virus-related diseases: a pictorial review

  title={Spectrum of Epstein-Barr virus-related diseases: a pictorial review},
  author={Eriko Maeda and Masaaki Akahane and Shigeru Kiryu and Nobuyuki Kato and Takeharu Yoshikawa and Naoto Hayashi and Shigeki Aoki and Manabu Minami and Hiroshi Uozaki and Masashi Fukayama and Kuni Ohtomo},
  journal={Japanese Journal of Radiology},
Epstein-Barr virus (EBV) prevails among more than 90% of the adult population worldwide. Most primary infections occur during young childhood and cause no or only nonspecific symptoms; then the virus becomes latent and resides in lymphocytes in the peripheral blood. Inactive latent EBV usually causes no serious consequences, but once it becomes active it can cause a wide spectrum of malignancies: epithelial tumors such as nasopharyngeal and gastric carcinomas; mesenchymal tumors such as… 

Pathogenesis and FDG-PET/CT findings of Epstein–Barr virus-related lymphoid neoplasms

The pathogenesis of EBV-related lymphoid neoplasms is described and FDG-PET/CT images of representative diseases are presented, including infectious mononucleosis and nasopharyngeal carcinoma, which are related to EBV infection.


The focus of this review is on the morphology, transmission and carcinogenic properties of Epstein-Barr virus and clinical and diagnostic aspects of a range of EBV-associated malignancies occurring in the head, neck and oral region.

Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis

Clinical and epidemiological features of EBV- associated tumors are summarized and how EBV latent genes may lead to oncogenesis in the different clinical malignancies are discussed.

Diabetes, Epstein-Barr virus and extranodal natural killer/T-cell lymphoma in India: Unravelling the plausible nexus

The epidemiological evidence linking various neoplasms with Type 2 DM and prognosticates the emergence of ENKTCL as a common lymphoreticular malignancy secondary to Type 2 diabetes, in the Indian population in the next few decades are reviewed.

Epstein-Barr Virus Positive Follicular Lymphoma of Lymph Node

A 59-year-old woman who underwent an excisional biopsy for a left axillary mass under suspicion of malignant lymphoma is reported a rare case of EBV associated FL of lymph node with its review of literature.

Lymphoma infectious mononucleosis by Epstein-Barr virus: A case report

Atypical presentation should be considered for every child and biopsy is inevitable in larger and persistent lymphadenopathy after 2 weeks, because of poor prognosis and high mortality rate, early detection of lymphoma is very important.

Epstein‐Barr virus‐induced polyclonal lymphoproliferative disorder of lymphoplasmacytic type in an autopsy case of aplastic anemia treated twice with anti‐thymocyte globulin therapy

LPD seen in an autopsy case of aplastic anemia after immunosuppressive therapy using anti-thymocyte globulin (ATG) twice is reported, and EBV-infected highly proliferative lymphoplasmacytic cells showed polyclonality.

Epstein-Barr virus and its association with disease - a review of relevance to general practice

Hepatitis is a common and self-limiting early complication to infectious mononucleosis and should be monitored with liver tests in more symptomatic cases, as well as possible late conditions; lymphoproliferative cancers, multiple sclerosis, rheumatoid arthritis, and chronic active Epstein-Barr virus infection.

Detection of Epstein – Barr virus in Pediatric Lymphoma : A Single Center Study

EBV infection may be a factor involved in the high incidence of pediatric lymphoma; this study suggests a positive influence of EBV infection in pediatric lymphomas.

The prevalence of Epstein-Barr virus infection in different types and sites of lymphomas.

Findings suggest that the EBV-positivity rate in lymphomas is related to their histological types and locations.



Senile EBV+ B-Cell Lymphoproliferative Disorders: A Clinicopathologic Study of 22 Patients

It is suggested that Epstein-Barr virus-associated LPD without immunodeficiency mainly occurs in elderly patients, and there was a significant difference in prognosis between the group with polymorphic LPDs and the one with large cell lymphomas.

AIDS‐related lymphomas: from pathogenesis to pathology

The KSHV/HHV8‐associated solid lymphomas are unusual lymphomas that occur more specifically in HIV‐positive patients; extracavitary and arise in nodal and/or extranodal sites; and histologically, they usually display a PEL‐like morphology and plasma cell‐related phenotype.

Pathology and molecular pathology of Epstein-Barr virus-associated gastric carcinoma.

Recent advances in molecular biological techniques have demonstrated that an unexpectedly wide variety of neoplasms in the general population is associated with EBV infection, among which EBV-associated gastric carcinoma (EBVaGC) is the most common with a worldwide distribution.

Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis.

It is hypothesized that most cases of lymphomatoid granulomatosis involving the lung represent a proliferation of Epstein-Barr virus infected B-cells with a prominent T-cell reaction and vasculitis, distinguishing these cases from angiocentric "T-cell lymphomas" in other sites, such as the head and neck.

Epstein–Barr virus‐associated Hodgkin's lymphoma

Increased knowledge of the virus’ role in the basic biology of HL may generate novel therapeutic strategies for EBV‐positive HL and the presence of EBV•latent antigens in the malignant HL cells may represent a target for cellular immunotherapy.

Adult Burkitt leukemia and lymphoma.

Although Burkitt lymphoma cells are extremely chemosensitive, biologically targeted therapies should be developed because current treatment options are suboptimal for patients with poor prognostic features or in the setting of relapsed disease.

Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus.

It is recommended that these malignant lymphomas be designated primary effusion lymphomas (PEL), rather than body cavity-based lymphomas, since this term describes them more accurately and avoids their confusion with other malignant cancerous lymphomas that occur in the body cavities.

Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour.

The imaging findings of an IPT-like follicular dendritic cell tumour and two EBV-positive inflammatory pseudotumours in two female patients and one male patient are described and attention should be paid to this new entity in the diagnosis of splenic lesions because of its neoplastic nature.

Epstein-Barr virus in pyothorax-associated pleural lymphoma.

The findings suggest that EBV is causally associated with the pleural lymphomas that originate at the site of chronic inflammation and fibrosis with a latent period of more than 40 years.

Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor: A Distinctive Low-Grade Malignant Intra-abdominal Neoplasm With Consistent Epstein–Barr Virus Association

Indolent behavior despite an intra-abdominal location; dispersed distribution of tumor cells and prominent lymphoplasmacytic infiltration; and consistent association with EBV are identified.