Spectrum of Epithelial Neoplasms in End-Stage Renal Disease: An Experience From 66 Tumor-Bearing Kidneys With Emphasis on Histologic Patterns Distinct From Those in Sporadic Adult Renal Neoplasia

@article{Tickoo2006SpectrumOE,
  title={Spectrum of Epithelial Neoplasms in End-Stage Renal Disease: An Experience From 66 Tumor-Bearing Kidneys With Emphasis on Histologic Patterns Distinct From Those in Sporadic Adult Renal Neoplasia},
  author={Satish K. Tickoo and Mariza Deperalta-Venturina and Lara R. Harik and Heath D Worcester and Mohamed E. Salama and Andrew N. Young and Holger Moch and Mahul B. Amin},
  journal={The American Journal of Surgical Pathology},
  year={2006},
  volume={30},
  pages={141-153}
}
Most (up to 71%) of renal cell neoplasms occurring in patients with end-stage renal disease (ESRD), particularly with acquired cystic disease of the kidney (ACDK), have been reported to be papillary renal cell carcinoma (RCC). Our initial experience with tumors in such a setting indicated that many tumors were histologically difficult to classify into the known subtypes of RCC or had features that were different from those in sporadically occurring RCCs. In this study on 66 ESRD kidneys (52 of… 
Clear Cell-Papillary Renal Cell Carcinoma of the Kidney Not Associated With End-stage Renal Disease: Clinicopathologic Correlation With Expanded Immunophenotypic and Molecular Characterization of a Large Cohort With Emphasis on Relationship With Renal Angiomyoadenomatous Tumor
TLDR
It is confirmed that CC-Pap RCC is a unique subtype of adult renal epithelial neoplasia in which tumors are frequently small, are of low nuclear grade and pathologic stage, and have extremely favorable short to intermediate range prognosis.
Acquired Cystic Disease-associated Renal Cell Carcinoma (ACD-RCC): A Multiinstitutional Study of 40 Cases With Clinical Follow-up
TLDR
The largest clinicopathologic series of ACD-RCC to date is presented and previously unreported cystic patterns of local soft tissue involvement and recurrence/metastases are described.
Pathological Interpretation of Renal Mass Biopsies
TLDR
This chapter will describe the most common renal neoplasms, highlighting their main morphologic features and diagnostic immunohistochemical properties.
Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution
TLDR
The aim was to describe the morphologic, immunohistochemical, and clinical characteristics of these tumors, finding 37 tumors with morphologic overlap between CCRCC and CCPRCC, identifying 2 patterns of renal neoplasia.
Clear Cell Papillary Renal Cell Carcinoma: A Distinct Histopathologic and Molecular Genetic Entity
TLDR
Clear cell papillary renal cell carcinoma can arise in otherwise normal kidneys and in kidneys with end-stage renal disease, and should be considered a distinct entity in the spectrum of renal cell neoplasia.
Pathology of Renal Cell Carcinoma
TLDR
This chapter aims to describe the histological, immunohistochemical, and genetic characteristics of RCCs that are useful for the differential diagnosis.
Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma.
TLDR
Recognition of CCRCC and differentiation from other renal cell neoplasms with clear cytoplasm is important not only for prognostication but also for treatment-related reasons.
...
...

References

SHOWING 1-10 OF 48 REFERENCES
Renal cell carcinoma of end-stage renal disease: a histopathologic and molecular genetic study.
TLDR
The findings indicate that the genetic changes underlying the development of most ESRD tumors are different from those occurring in sporadic clear cell RCC and do not characteristically involve the inactivation of a 3p tumor suppressor gene.
Prognostic Impact of Histologic Subtyping of Adult Renal Epithelial Neoplasms: An Experience of 405 Cases
TLDR
It is shown that the histologic categorization of adult renal epithelial neoplasms performed by routine light microscopic hematoxylin and eosin-based examination in accordance with the contemporary classification scheme has prognostic utility.
Distribution of Cytokeratins and Vimentin in Adult Renal Neoplasms and Normal Renal Tissue: Potential Utility of a Cytokeratin Antibody Panel in the Differential Diagnosis of Renal Tumors
TLDR
The purpose of this study was to determine the diagnostic utility of cytokeratin (CK) subtype expression pattern in a wide range of adult RENs and found that CK expression patterns may be useful in several differential diagnostic settings.
Calcium Oxalate Deposition in Renal Cell Carcinoma Associated With Acquired Cystic Kidney Disease: A Comprehensive Study
TLDR
Proximal tubular cell differentiation in conjunction with ESRD-mediated high serum level may be pathogenetically important for intratumoral CaOx deposition and these RCCs seems to have a relatively good prognosis.
Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis.
TLDR
By pathologic analysis, renal tumors are more common in the pre-transplant ESRD population than previously reported (using radiologic methods) and this study also identifies risk factors for their occurrence.
Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations.
Acquired renal cystic disease (ARCD) complicating end-stage renal failure confers an increased risk for renal cell carcinoma, and atypical epithelial proliferation in the cysts may represent the
Renal cell carcinoma in native kidneys of patients with end stage renal disease.
TLDR
Patients with end stage renal disease have an increased prevalence of renal cell carcinoma and the need is to identify patients at high risk for the development of this disease and perform annual screening.
Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis.
TLDR
Most of the cancers are found incidentally at autopsy or by examination of kidneys from bilateral nephrectomies and are of little clinical significance, but occasional cases present aggressive neoplasms that metastasize and cause the deaths of patients.
Sarcomatoid collecting duct carcinoma arising in the hemodialysis‐associated acquired cystic kidney: An autopsy report
TLDR
Although sarcomatoid collecting duct carcinoma is not common in acquired cystic kidney disease patients, attention should be given to the occurrence of high‐grade carcinoma of rare histological variant, as well as conventional renal cell carcinoma.
...
...