Spectrum of Cytogenomic Abnormalities Revealed by Array Comparative Genomic Hybridization on Products of Conception Culture Failure and Normal Karyotype Samples.

@article{Zhou2016SpectrumOC,
  title={Spectrum of Cytogenomic Abnormalities Revealed by Array Comparative Genomic Hybridization on Products of Conception Culture Failure and Normal Karyotype Samples.},
  author={Qinghua Zhou and Shen-Yin Wu and Katherine R. Amato and Autumn J DiAdamo and Peining Li},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  year={2016},
  volume={43 3},
  pages={121-31}
}
Approximately 30% of pregnancies after implantation end up in spontaneous abortions, and 50% of them are caused by chromosomal abnormalities. However, the spectrum of genomic copy number variants (CNVs) in products of conception (POC) and the underlying gene-dosage-sensitive mechanisms causing spontaneous abortions remain largely unknown. In this study, array comparative genomic hybridization (aCGH) analysis was performed as a salvage procedure for 128 POC culture failure (POC-CF) samples and… CONTINUE READING

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Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
A rationalized approach using firstly fluorescence in situ hybridization ( FISH ) testing with probes of chromosomes X / Y/18 , 13/21 , and 15/16/22 for common aneuploidies and polyploidies and secondly aCGH for other cytogenomic abnormalities is recommended for POC - CF samples .
A rationalized approach using firstly fluorescence in situ hybridization ( FISH ) testing with probes of chromosomes X / Y/18 , 13/21 , and 15/16/22 for common aneuploidies and polyploidies and secondly aCGH for other cytogenomic abnormalities is recommended for POC - CF samples .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
The denoted primary gene networks suggested that apoptosis and cell proliferation pathways are involved in miscarriage .
The denoted primary gene networks suggested that apoptosis and cell proliferation pathways are involved in miscarriage .
Approximately 30% of pregnancies after implantation end up in spontaneous abortions , and 50% of them are caused by chromosomal abnormalities .
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