Spectrum of Cognitive Impairment in Korean ALS Patients without Known Genetic Mutations

  title={Spectrum of Cognitive Impairment in Korean ALS Patients without Known Genetic Mutations},
  author={Seong-il Oh and Aram Park and Hee-Jin Kim and Ki-Wook Oh and Hojin Choi and Min-Jung Kwon and Chang Seok Ki and Helen F. Kim and Seung Hyun Kim},
  booktitle={PloS one},
BACKGROUND Cognitive impairment is associated with a negative prognosis in amyotrophic lateral sclerosis (ALS), as well as with clinical specificity. We investigate neuropsychological function in ALS patients without known genetic mutations in a Korean tertiary clinic. METHODS Three hundred and eighteen patients were enrolled in a prospective longitudinal cohort from September 2008 to February 2012. At the time of diagnosis of sporadic ALS, we carried out genetic and comprehensive… CONTINUE READING


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