Spectrum of AIDS-associated malignant disorders

@article{Goedert1998SpectrumOA,
  title={Spectrum of AIDS-associated malignant disorders},
  author={James J. Goedert and Timothy R. Cot{\'e} and Phillip Virgo and Steve Scoppa and Douglas W. Kingma and Mitchell H. Gail and Elaine S. Jaffe and Robert J. Biggar},
  journal={The Lancet},
  year={1998},
  volume={351},
  pages={1833-1839}
}
AIDS-related cancer and severity of immunosuppression in persons with AIDS.
TLDR
CD4 count was strongly associated with risks for Kaposi sarcoma and non-Hodgkin lymphoma but not for cervical cancer and Burkitt lymphoma, consistent with improving CD4 counts after HAART introduction in 1996.
Association of cancer with AIDS-related immunosuppression in adults.
TLDR
Although occurring in overall excess, most non-AIDS-defining cancers do not appear to be influenced by the advancing immunosuppression associated with HIV disease progression.
Epidemiology of AIDS-related tumours in developed and developing countries.
Risk of Cancer in Children With AIDS
TLDR
The spectrum of AIDS-associated pediatric cancers resembled that seen in adults, with the addition of leiomyosarcoma, and RR estimates are imprecise and caution is warranted in their interpretation.
Immune Deficiency and Risk for Malignancy Among Persons with AIDS
TLDR
KS and NHL risk increased with level of immunosuppression at AIDS onset and non-AIDS-defining cancers, including cervical cancer, were unrelated to CD4 counts.
Rates of non-AIDS-defining cancers in people with HIV infection before and after AIDS diagnosis
TLDR
There is reassuring evidence that people with HIV who are only mildly immune deficient may not be at increased risk of non-AIDS-defining cancers, but larger studies with longer periods of follow-up are needed to confirm this.
Epidemiology of AIDS-Associated malignances
TLDR
The evidence for an increased risk of Kaposi's sarcoma and non-Hodgkin's lymphoma in HIV-infected people is consistent and KS and NHL have, since the early days of the epidemic, been among the so-calledAIDS-defining illnesses.
Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007.
TLDR
The estimated proportions of AIDS-defining malignancies that occurred among persons with AIDS were substantial, particularly for KS and some NHLs, and the rates were applied to national AIDS surveillance and US Census data.
The Epidemiology of Cancer in People with HIV
Three types of cancer, namely Kaposi’s sarcoma (KS), non-Hodgkin’s lymphoma (NHL), and cervical cancer, are formally designated as AIDS-defining cancers. KS occurs many thousandfold more commonly in
Long-term Cancer Risk among People Diagnosed with AIDS during Childhood
TLDR
People diagnosed with AIDS during childhood remain at elevated risk for KS, NHL, and leiomyosarcoma in the HAART era, and continued monitoring is warranted as this immunosuppressed population ages into adulthood where cancer risks generally increase.
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