Spectroscopic methodologies and molecular docking studies on the interaction of antimalarial drug piperaquine and its metabolites with human serum albumin.

@article{Ma2019SpectroscopicMA,
  title={Spectroscopic methodologies and molecular docking studies on the interaction of antimalarial drug piperaquine and its metabolites with human serum albumin.},
  author={Rui Ma and Dong-Xiao Guo and Huifen Li and Huixiang Liu and Yun-Rui Zhang and J. Ji and J. Xing and Shu-Qi Wang},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2019},
  volume={222},
  pages={
          117158
        }
}
Artemisinin-based combination therapy is widely used for the treatment of uncomplicated Plasmodium falciparum malaria, and piperaquine (PQ) is one of the important partner drugs. During the biotransformation of PQ, M1 (N-oxidation product), M2 (N-oxidation product), M3 (carboxylic acid product), M4 (N-dealkylation product), and M5 (N-oxidated product of M4) are formed by cytochrome P450 pathways. Despite decades of clinical use, the interactions between PQ and its main metabolites (PQs) with… Expand
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STRUCTURAL-FUNCTIONAL ANALYSIS OF BIOPOLYMERS AND THEIR COMPLEXES
  • 2019

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