Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

  title={Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel},
  author={K. Glauner and L. Mannuzzu and C. S. Gandhi and E. Isacoff},
  • K. Glauner, L. Mannuzzu, +1 author E. Isacoff
  • Published 1999
  • Chemistry, Medicine
  • Nature
  • Voltage-gated ion channels underlie the generation of action potentials and trigger neurosecretion and muscle contraction. These channels consist of an inner pore-forming domain, which contains the ion permeation pathway and elements of its gates, together with four voltage-sensing domains, which regulate the gates. To understand the mechanism of voltage sensing it is necessary to define the structure and motion of the S4 segment, the portion of each voltage-sensing domain that moves charged… CONTINUE READING
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