Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

@article{Glauner1999SpectroscopicMO,
  title={Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel},
  author={K. Glauner and L. Mannuzzu and C. S. Gandhi and E. Isacoff},
  journal={Nature},
  year={1999},
  volume={402},
  pages={813-817}
}
  • K. Glauner, L. Mannuzzu, +1 author E. Isacoff
  • Published 1999
  • Chemistry, Medicine
  • Nature
  • Voltage-gated ion channels underlie the generation of action potentials and trigger neurosecretion and muscle contraction. These channels consist of an inner pore-forming domain, which contains the ion permeation pathway and elements of its gates, together with four voltage-sensing domains, which regulate the gates. To understand the mechanism of voltage sensing it is necessary to define the structure and motion of the S4 segment, the portion of each voltage-sensing domain that moves charged… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Characterizing Voltage-Dependent Conformational Changes in the ShakerK+ Channel with Fluorescence
    • 315
    Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel
    • 315
    Evidence for voltage-dependent S4 movement in sodium channels
    • 413