Spectroscopic and structural study of flobufen

  title={Spectroscopic and structural study of flobufen},
  author={Alexandr Jegorov and Petr Sedmera and Vladim{\'i}r Havl{\'i}{\vc}ek and Michal Hu{\vs}{\'a}k and Svetlana Pakhomova and Bohumil Kratochvil and Miroslav Kuchař and Petr Bulej},
Abstract Flobufen, 4-(2′,4′-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoicacid, and its 3-methyl isomer have been obtained by the Friedel-Crafts reaction of 2,4-difluorobiphenyl with itaconic or citraconic anhydride, respectively, followed by hydrogenation of the products. The structures of both compounds have been elucidated by mass spectrometry and 1 H, 13 C and 19 F NMR spectroscopy. The structure of flobufen has been confirmed by a single-crystal X-ray study. 


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