Spectroscopic and molecular modeling studies of caffeine complexes with DNA intercalators.

@article{Larsen1996SpectroscopicAM,
  title={Spectroscopic and molecular modeling studies of caffeine complexes with DNA intercalators.},
  author={Randy W. Larsen and Ravi Jasuja and Ronald K. Hetzler and Peter T. Muraoka and V G Andrada and David Jameson},
  journal={Biophysical journal},
  year={1996},
  volume={70 1},
  pages={443-52}
}
Recent studies have demonstrated that caffeine can act as an antimutagen and inhibit the cytoxic and/or cytostatic effects of some DNA intercalating agents. It has been suggested that this inhibitory effect may be due to complexation of the DNA intercalator with caffeine. In this study we employ optical absorption, fluorescence, and molecular modeling techniques to probe specific interactions between caffeine and various DNA intercalators. Optical absorption and steady-state fluorescence data… CONTINUE READING

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