Spectroscopic analysis of [Trp3]-beta-casomorphin analogs. Comparative structure conformation-activity studies.

@article{Epps1991SpectroscopicAO,
  title={Spectroscopic analysis of [Trp3]-beta-casomorphin analogs. Comparative structure conformation-activity studies.},
  author={D. E. Epps and H. Havel and T. Sawyer and D. Staples and N. Chung and P. Schiller and B. Hartrodt and A. Barth},
  journal={International journal of peptide and protein research},
  year={1991},
  volume={37 4},
  pages={
          257-67
        }
}
  • D. E. Epps, H. Havel, +5 authors A. Barth
  • Published 1991
  • Chemistry, Medicine
  • International journal of peptide and protein research
    • A series of [3-tryptophan]-beta-casomorphin-5([Trp3]-beta-CM-5) analogs were investigated by circular dichroism (CD) and fluorescence spectroscopy to explore their structure-conformation properties in solution. In addition, the comparative opioid activities of these compounds were evaluated using the in vitro guinea pig ileum (GPI) and mouse vas deferens (MVD) assays. Specifically, the pentapeptide sequence of [Trp3]-beta-CM-5, H-Tyr-Pro-Trp-Pro-Gly-OH (I) was modified at Pro-2 and Pro-4 by D… CONTINUE READING
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    β-Casomorphin: A complete health perspective.
    5 – Peptide Conformation: Stability and Dynamics
    • 7

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