Synthesis, DNA-binding study, and antioxidant activity of 14-aryl-14H-dibenzo[a,j]xanthene derivatives
The binding of Hypocrellin B-TiO2 chelate with DNA has been studied by using absorption, steady state fluorescence, cyclic voltammetry, time resolved fluorescence and laser flash photolysis measurements. The experimental results show that the presence of TiO2 nanoparticles increases the binding of Hypocrellin B with DNA. The groove binding mode is confirmed by spectroscopic and docking studies. Laser flash photolysis studies confirm the presence of electrons in the conduction band of TiO2 which will produce active oxygen species and results in damage of DNA indicating the potential application of Hypocrellin B-TiO2 chelate in the field of photodynamic therapy (PDT).