Spectrophotometric study of alpha-adrenoceptors affecting microcirculation of rat skin.

@article{Kakizoe1993SpectrophotometricSO,
  title={Spectrophotometric study of alpha-adrenoceptors affecting microcirculation of rat skin.},
  author={Eiichi Kakizoe and Yutaka Kobayashi and Keiko Shimoura and Kaoru Hattori and J Jidoi},
  journal={Clinical and experimental pharmacology & physiology},
  year={1993},
  volume={20 6},
  pages={421-7}
}
1. To determine the alpha-adrenergic receptor subtypes that affect the microcirculation of skin, the relative absorption (RA) spectra of the skin on the backs of rats were measured using reflectance spectrophotometric methods. We injected alpha-adrenergic agonists, noradrenaline (NA), phenylephrine (PE) and clonidine (CL), intravenously and determined changes in the RA value at 569 nm, one of the isosbestic points of the oxyhaemoglobin and deoxyhaemoglobin absorption. 2. NA reduced the RA value… CONTINUE READING
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