Spectrin: Structure, function and disease

@article{Zhang2013SpectrinSF,
  title={Spectrin: Structure, function and disease},
  author={Rui Kai Zhang and Chenyu Zhang and Qi Zhao and Donghai Li},
  journal={Science China Life Sciences},
  year={2013},
  volume={56},
  pages={1076-1085}
}
Spectrin is a large, cytoskeletal, and heterodimeric protein composed of modular structure of α and β subunits, it typically contains 106 contiguous amino acid sequence motifs called “spectrin repeats”. Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a cell. Moreover, it contributes to diverse cell functions such as cell adhesion, cell spreading, and the cell cycle. Mutations of spectrin lead to various human diseases such as hereditary… CONTINUE READING
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