Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin.

@article{MacLaughlin1982SpectralCO,
  title={Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin.},
  author={Julia A. MacLaughlin and R Rox Anderson and Michael F Holick},
  journal={Science},
  year={1982},
  volume={216 4549},
  pages={
          1001-3
        }
}
The photosynthesis of previtamin D3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D3. In comparison, when adjacent skin was exposed to simulated solar radiation… Expand
Vitamin D Metabolism and the Clinical Aspects of Measuring Metabolites
  • S. J. Iqbal
  • Biology, Medicine
  • Annals of clinical biochemistry
  • 1994
TLDR
Results show that continued exposure to sunlight results in the formation of biologically inert products and sunlight regulates the production of previtamin D and vitamin D] and limits the systemic availability of vitamin D]. Expand
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  • M. Holick
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1988
TLDR
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  • 1995
TLDR
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References

SHOWING 1-10 OF 11 REFERENCES
Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator.
TLDR
Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. Expand
Photosynthesis of previtamin D3 in human skin and the physiologic consequences.
TLDR
These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D3 from the skin into the circulation. Expand
Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation.
TLDR
The process of the photolytic activation of vitamin D precursor(s) in the skin has been elucidated by a detailed analysis of the products formed after ultraviolet light exposure, and Vitamin D3 arises exclusively from the thermal conversion of previtamin D3. Expand
A rapid and precise method for the determination of vitamin D3 in rat skin by high-performance liquid chromatography.
TLDR
The most effective wavelength for the formation of vitamin D3 was confirmed to be 303 nm, which differs from the result obtained from the experiment in a test tube (295 nm), which was thought to be due to the filter effect of the malpighian layer in the epidermis of rat skin. Expand
The effects of light on the human body.
  • R. Wurtman
  • Physics, Medicine
  • Scientific American
  • 1975
TLDR
The influences of light on human health is explored and it is suggested that exposure to artificial light may have harmful effects and health considerations should be incorporated into the design of light environments. Expand
THE MIDDLE ULTRAVIOLET REACHING THE GROUND *
Abstract— We present a semi‐empirical analytic formula for calculating the direct, diffuse and global solar middle‐ultraviolet radiation (280–340 nm) reaching the ground. The formula accommodatesExpand
) , op . 5981 . 9 . E . Havinga , Experientia
  • Biological Effects of Ultraviolet Radiation
  • 1978
UVA: Biological Effects of Ultraviolet Radiation (Plenum
  • New York,
  • 1978
Shettle, Photo-chem
  • Photobiol. 19,
  • 1974
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1
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