Spectral changes associated with binding of folate compounds to bacteriophage T4 dihydrofolate reductase.

@article{Erickson1972SpectralCA,
  title={Spectral changes associated with binding of folate compounds to bacteriophage T4 dihydrofolate reductase.},
  author={Jerry Erickson and Christopher K . Mathews},
  journal={The Journal of biological chemistry},
  year={1972},
  volume={247 18},
  pages={
          5661-7
        }
}
The difference spectra associated with complex formation at pH 7.0 between bacteriophage T4-specific dihydrofolate reductase and the 4-amino folate analogues, aminopterin, methotrexate, and N1o-formyl-aminopterin, have features which are similar to the difference spectra obtained for the free compounds in acid versus neutral solutions. These results suggest that oxidized 4-amino-folate compounds bind to T4 Hz-folate reductase in the cationic form. This similarity does not extend to the… CONTINUE READING

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Cancer Chemother. Rep. 4, 1 by gest on O cber 14

  • J. P. PERKINS, J. R. BERTINO
  • J. Biol. Chem
  • 1972

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