Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains.

@article{Kpfer1982SpectralBS,
  title={Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains.},
  author={Adrian K{\"u}pfer and S. G. Al-Dabbagh and James Carl Ritchie and Jeffrey R Idle and Robert L. Smith},
  journal={Biochemical pharmacology},
  year={1982},
  volume={31 20},
  pages={3193-9}
}
The mechanisms of polymorphic drug hydroxylation of debrisoquine, sparteine and related drugs in vivo have been investigated using Cyt P-450 preparations of inbred rat strains as an in vitro model of the poor and extensive metabolizer phenotypes found in various rat strains and in man. Optical difference spectroscopy with debrisoquine, sparteine, phenformin and three other drugs (selected test compounds with proven or suspected hydroxylation polymorphisms in man) exhibited Type 1 binding in… CONTINUE READING
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