Spectral and molecular modeling studies on the influence of β-cyclodextrin and its derivatives on aripiprazole-human serum albumin binding.

  title={Spectral and molecular modeling studies on the influence of $\beta$-cyclodextrin and its derivatives on aripiprazole-human serum albumin binding.},
  author={Jin Yan and Di Wu and Xiao-li Ma and Lili Wang and Kai Lin Xu and Hui Li},
  journal={Carbohydrate polymers},
  • Jin Yan, Di Wu, +3 authors H. Li
  • Published 2015
  • Chemistry, Medicine
  • Carbohydrate polymers
The binding mechanism of aripiprazole (APZ) with human serum albumin (HSA) in the absence and presence of three cyclodextrins (CyDs) (β-cyclodextrin, hydroxypropyl-β-cyclodextrin, and (2,6-di-O-methyl)-β-cyclodextrin) was studied by fluorescence, ultraviolet-visible absorption, nuclear magnetic resonance, and circular dichroism (CD) spectroscopy. The CD results revealed some degree of recovery of refolding caused by APZ after the addition of CyD. The Stern-Volmer quenching constant and binding… Expand
Competitive Binding of Tolmetin to β-Cyclodextrin and Human Serum Albumin: 1H NMR and Fluorescence Spectroscopy Studies
The host–guest interaction of tolmetin (TOL) with β-cyclodextrin (β-CD) and the influence of human serum albumin (HSA) on the formation of the inclusion complex were studied by 1D and 2D NMRExpand
The influence of hydroxypropyl-β-cyclodextrin on the solubility, dissolution, cytotoxicity, and binding of riluzole with human serum albumin.
  • Lili Wang, Jin Yan, +4 authors H. Li
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 2016
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The binding abilities of α- and β-cyclodextrins (α-CD and β-CD) with some heterocyclic azo compounds (1,1'-(azodicarbonyl)dipiperidine (ADP) and azodicarboxylic dimorpholide (ADM)) were studied atExpand
Spectroscopy and molecular docking approach for investigation on the binding of nocodazole to human serum albumin.
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Results indicated that a riociguat-HSA complex was formed and that the protein secondary structure was altered by the addition of ri OCguat, and Alterations in theprotein secondary structure after drug complexation were predicted. Expand
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HαCD, HPγCD and PEG400 seemed to be the excipients more suitable for use in topical preparations containing Lc, which showed a modest interaction between Lc and HSA which was reduced mainly by HPβCD. Expand
Comparative analysis the binding affinity of mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR relaxation data and docking simulation.
The binding ability of mycophenolic sodium and meprednisone toward human serum albumin is analyzed by nuclear magnetic resonance relaxation data and docking simulation and the calculation of the affinity index is compared. Expand


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Abstract We describe, in this article, the associative interaction between Linezolid and β-Cyclodextrin, and the influence of β-Cyclodextrin on Linezolid's binding to Bovine serum albumin.Expand
Investigation on the Interaction between Cyclophosphamide and Lysozyme in the Presence of Three Different Kind of Cyclodextrins: Determination of the Binding Mechanism by Spectroscopic and Molecular Modeling Techniques
The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in the presence of different cyclodextrins (CDs) were investigated by UV absorption, fluorescence spectroscopy, circular dichroismExpand
The role of encapsulation by β-cyclodextrin in the interaction of raloxifene with macromolecular targets: a study by spectroscopy and molecular modeling
It is inferred that the binding strengths between raloxifene and macromolecules, viz., ctDNA and BSA are influenced by the β-CD encapsulation, which may suggest new ways to tune the drug binding to biomacromolecule by encapsulating specific moieties of drugs. Expand
Alteration of the Binding Strength of Dronedarone with Bovine Serum Albumin by β-Cyclodextrin: A Spectroscopic Study
We report the influence of β-cyclodextrin on the binding of the drug dronedarone with bovine serum albumin. The stoichiometry, the binding constant, and the mode of binding of the derivative withExpand
From guest to ligand – A study on the competing interactions of antitumor drug resveratrol with β-cyclodextrin and bovine serum albumin
Abstract Interaction between bovine serum albumin (BSA) and resveratrol (RES) included by β-cyclodextrin (β-CD) in Tris–HCl aqueous buffer solutions (pH 7.4) has been investigated by isothermalExpand
Interactions of some modified mono- and bis-beta-cyclodextrins with bovine serum albumin.
Results indicate that the modified cyclodextrins can interact with BSA and the bridged bis(beta-cyclodextrin)s have much stronger interactions than the mono-substituted beta-cyclodesxtrins (1 and 2). Expand
Interaction of cyclodextrins with human and bovine serum albumins: A combined spectroscopic and computational investigation
AbstractInteraction of cyclodextrins (CDs) with the two most abundant proteins, namely human serum albumin (HSA) and bovine serum albumin (BSA), has been investigated using steady-state andExpand
Binding of the iminium and alkanolamine forms of sanguinarine to lysozyme: spectroscopic analysis, thermodynamics, and molecular modeling studies.
The docking results are in accordance with the spectroscopic and thermodynamic data, further validating the stronger binding of SGRA over SGRI to Lyz and the putative anticancer alkaloid sanguinarine and lysozyme. Expand
Investigations of the interactions of peimine and peiminine with human serum albumin by spectroscopic methods and docking studies
The primary objective of this study is to evaluate the interactions of human serum albumin (HSA) with peimine (PE) and peiminine (PEN) in physiological conditions by fluorescence spectroscopy,Expand
Calorimetric and spectroscopic characterization of complexes between β-cyclodextrin or heptakis (2,6-di-O-methyl)-β-cyclodextrin and sertraline hydrochloride in aqueous solution
Abstract The interaction of sertraline hydrochloride (SRT) with β-cyclodextrin (β-CD) and heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) in aqueous solutions was investigated using the methods ofExpand