Spectral and molecular modeling studies on the influence of β-cyclodextrin and its derivatives on aripiprazole-human serum albumin binding.

@article{Yan2015SpectralAM,
  title={Spectral and molecular modeling studies on the influence of $\beta$-cyclodextrin and its derivatives on aripiprazole-human serum albumin binding.},
  author={Jin Yan and Di Wu and Xiao-li Ma and Lili Wang and Kai Lin Xu and Hui Li},
  journal={Carbohydrate polymers},
  year={2015},
  volume={131},
  pages={
          65-74
        }
}
  • Jin Yan, Di Wu, +3 authors H. Li
  • Published 2015
  • Chemistry, Medicine
  • Carbohydrate polymers
The binding mechanism of aripiprazole (APZ) with human serum albumin (HSA) in the absence and presence of three cyclodextrins (CyDs) (β-cyclodextrin, hydroxypropyl-β-cyclodextrin, and (2,6-di-O-methyl)-β-cyclodextrin) was studied by fluorescence, ultraviolet-visible absorption, nuclear magnetic resonance, and circular dichroism (CD) spectroscopy. The CD results revealed some degree of recovery of refolding caused by APZ after the addition of CyD. The Stern-Volmer quenching constant and binding… Expand
Competitive Binding of Tolmetin to β-Cyclodextrin and Human Serum Albumin: 1H NMR and Fluorescence Spectroscopy Studies
The host–guest interaction of tolmetin (TOL) with β-cyclodextrin (β-CD) and the influence of human serum albumin (HSA) on the formation of the inclusion complex were studied by 1D and 2D NMRExpand
The influence of hydroxypropyl-β-cyclodextrin on the solubility, dissolution, cytotoxicity, and binding of riluzole with human serum albumin.
  • Lili Wang, Jin Yan, +4 authors H. Li
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 2016
TLDR
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Voltammetric, spectroscopic and thermal studies on the binding of some heterocyclic azo compounds with α- and β-cyclodextrins: pH effect and association affinity
The binding abilities of α- and β-cyclodextrins (α-CD and β-CD) with some heterocyclic azo compounds (1,1'-(azodicarbonyl)dipiperidine (ADP) and azodicarboxylic dimorpholide (ADM)) were studied atExpand
Spectroscopy and molecular docking approach for investigation on the binding of nocodazole to human serum albumin.
TLDR
Synchronous, three-dimensional fluorescence and CD spectroscopic results reveal that the addition of Nz to HSA affects changes in the micro-environment and conformation of HSA. Expand
Spectroscopic methodologies and molecular docking studies on the interaction of the soluble guanylate cyclase stimulator riociguat with human serum albumin.
TLDR
Results indicated that a riociguat-HSA complex was formed and that the protein secondary structure was altered by the addition of ri OCguat, and Alterations in theprotein secondary structure after drug complexation were predicted. Expand
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AbstractLumichrome (Lc) is a photodegradation product of riboflavin that can be used as a photosensitizer (PS) in antibacterial photodynamic therapy (aPDT). The binding of Lc with plasma proteinsExpand
Interaction between the photosensitizer lumichrome and human serum albumin: effect of excipients
TLDR
HαCD, HPγCD and PEG400 seemed to be the excipients more suitable for use in topical preparations containing Lc, which showed a modest interaction between Lc and HSA which was reduced mainly by HPβCD. Expand
Comparative analysis the binding affinity of mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR relaxation data and docking simulation.
TLDR
The binding ability of mycophenolic sodium and meprednisone toward human serum albumin is analyzed by nuclear magnetic resonance relaxation data and docking simulation and the calculation of the affinity index is compared. Expand
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