Spectral Rate Theory for Two-State Kinetics.

  title={Spectral Rate Theory for Two-State Kinetics.},
  author={Jan-Hendrik Prinz and John D. Chodera and Frank No{\'e}},
  journal={Physical review. X},
  volume={4 1}
Classical rate theories often fail in cases where the observable(s) or order parameter(s) used is a poor reaction coordinate or the observed signal is deteriorated by noise, such that no clear separation between reactants and products is possible. Here, we present a general spectral two-state rate theory for ergodic dynamical systems in thermal equilibrium that explicitly takes into account how the system is observed. The theory allows the systematic estimation errors made by standard rate… 

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