Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.

@article{Giniger1993SpecifyingTP,
  title={Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.},
  author={Edward Giniger and Lily Yeh Jan and Yuh Nung Jan},
  journal={Development},
  year={1993},
  volume={117 2},
  pages={431-40}
}
The intersegmental nerve (ISN) of the Drosophila embryo follows a reproducible course near the anterior border of each segment. Based on the experiments reported here, we suggest that growth of the axons constituting the nerve is guided, in part, by the transmembrane proteins Delta and Notch. In particular, we suggest that expression of Delta protein on a branch of the trachea provides a path for the nerve through the lateral part of the embryo, and that the growing axons use the Notch protein… CONTINUE READING

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