Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition.

@article{Kolesnikoff2014SpecificityP1,
  title={Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition.},
  author={Natasha Kolesnikoff and Joanne L. Attema and Suraya Roslan and Andrew G. Bert and Quenten Schwarz and Philip A Gregory and Gregory J. Goodall},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 16},
  pages={
          11194-205
        }
}
Epithelial-mesenchymal transition (EMT) is required for the specification of tissues during embryonic development and is recapitulated during the metastatic progression of tumors. The miR-200 family plays a critical role in enforcing the epithelial state with their expression lost in cells undergoing EMT. EMT can be mediated by activation of the ZEB1 and ZEB2 (ZEB) transcription factors, which repress miR-200 expression via a self-reinforcing double negative feedback loop to promote the… CONTINUE READING

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