Specificity protein 1: Its role in colorectal cancer progression and metastasis.

@article{Bajpai2017SpecificityP1,
  title={Specificity protein 1: Its role in colorectal cancer progression and metastasis.},
  author={Richa Bajpai and Ganji Purnachandra Nagaraju},
  journal={Critical reviews in oncology/hematology},
  year={2017},
  volume={113},
  pages={
          1-7
        }
}
Specificity protein 1 (Sp1) is a widely expressed transcription factor that plays an important role in the promotion of oncogenes required for tumor survival, progression and metastasis. Sp1 is highly expressed in several cancers including colorectal cancer (CRC) and is related to poor prognosis. Therefore, targeting Sp1 is a rational for CRC therapy. In this review, we will recapitulate the current understanding of Sp1 signaling, its molecular mechanisms, and its potential involvement in CRC… CONTINUE READING
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