Specificity profiling of protein phosphatases toward phosphoseryl and phosphothreonyl peptides.

Abstract

A combinatorial library method was developed to systematically profile the substrate specificity of protein phosphatases toward phosphoseryl (pS) and phosphothreonyl (pT) peptides. Application of this method and a previously reported phosphotyrosyl (pY) library screening technique to dual-specificity phosphatase (DUSP) VH1 of vaccinia virus revealed that… (More)
DOI: 10.1021/ja401692t

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