Specificity of the TraA-DNA interaction in the regulation of the pPD1-encoded sex pheromone response in Enterococcus faecalis.

@article{Folli2008SpecificityOT,
  title={Specificity of the TraA-DNA interaction in the regulation of the pPD1-encoded sex pheromone response in Enterococcus faecalis.},
  author={Claudia Folli and Laura Mangiarotti and Silvia Folloni and Beatrice Alfieri and Marina Gobbo and Rodolfo Berni and Claudio Rivetti},
  journal={Journal of molecular biology},
  year={2008},
  volume={380 5},
  pages={932-45}
}
The Enterococcus faecalis conjugative plasmid pPD1 encodes proteins responsible for the mating response to the sex pheromone cPD1 secreted by a recipient cell. This response involves the respectively negative and positive determinants traA and traE, the pheromone-inhibitor determinant ipd and structural genes participating in the conjugation process. TraA is capable of binding to key sites within the regulatory gene cluster. The binding of TraA to cognate sites is modulated by the pheromone… CONTINUE READING