Specificity of the FTA-ABS and TPHA tests during pregnancy.

@article{ManikowskaLesiska1978SpecificityOT,
  title={Specificity of the FTA-ABS and TPHA tests during pregnancy.},
  author={W Manikowska-Lesińska and B Linda and W. Zajac},
  journal={The British Journal of Venereal Diseases},
  year={1978},
  volume={54},
  pages={295 - 298}
}
In order to determine whether pregnancy influences the specificity of the fluorescent treponemal antibody absorption (FTA-ABS) and Treponema palidum haemagglutination assay (TPHA) tests, these tests, together with the quantitative fluorescent treponemal antibody (FTA) and Venereal Disease Research Laboratory (VDRL) tests, were carried out simultaneously on 2000 pregnant women who attended for compulsory prenatal screening. In only one patient (0.05% of the total investigated) was a positive… 

Non-specific positive test results to syphilis in dermatological diseases.

TLDR
The test producing the most non-specific results was the FTA test, followed by the FTA-ABS test, the VDRL test, and Kolmer's test; these were found more frequently in patients with pyodermas, neoplasms, acne, mycoses, crural ulceration, and psoriasis than in those with other diseases.

Fluorescent Treponemal Antibody‐Absorption (FTA‐ABS) Test

  • J. Bos
  • Biology, Medicine
    International journal of dermatology
  • 1982
TLDR
The fluorescent treponemal antibody-absorption test was developed to avoid nonspecific positive reactions in the FTA-test, which is known as the ETA-.5 test, because test sera were used at a 1/5 dilution.

Depressed CD4/CD8 Ratio in TPHA‐Negative Patients with Syphilis

TLDR
The experience with six elderly patients with syphilis, whose TPHA was negative, suggests that the TPHA is insufficient for excluding elderly syphilitics because of immunological impairment seen in aged patients.

Comparative evaluation of commercial fluorescent treponemal antibody-absorbed test kits

TLDR
The development of an immunological standard for use in the manufacture of fluorescent treponemal antibody-absorbed test kits is recommended, with the goal of obtaining uniform performance characteristics among commercial test kits.

Syphilis tests in diagnostic and therapeutic decision making.

  • G. Hart
  • Medicine, Psychology
    Annals of internal medicine
  • 1986
TLDR
Predictive value calculations were used to derive diagnostic guidelines for syphilis and screening of asymptomatic persons with the VDRL test, followed by treponemal test confirmation on positive sera, is recommended for all pregnant women, contacts of persons with infectious syphilis, and other high-risk groups.

Evaluation and treatment of congenital syphilis.

Antenatal screening for syphilis at the University of Nigeria Teaching Hospital, Enugu, Nigeria — A six year survey

  • P. GiniW. ChukudebeluA. Njoku-Obi
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1989

Clinical Application Of Serological Tests For Syphilis SUMMARY

TLDR
The humoral response to T. pallidum invades the human host and multiple humoral antibodies are formed, of two types: antitreponemal antibodies and antibody-like substances known as reagin or lipoidal antibodies.

Clinical Focus: Infections in Pregnancy

TLDR
A review outlines the challenges associated with managing important infectious diseases in the pregnant population and references the most recent evidence and international treatment guidelines.

Obstetric infections.

  • H. Oster
  • Medicine, Biology
    The Western journal of medicine
  • 1981
TLDR
Altered physiological and immunological states during pregnancy are important in understanding the pathophysiology of maternal infections.

References

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FTA-ABS Test in Pregnancy: A Probable False-Positive Reaction

The fluorescent treponemal antibody absorption (FTA-ABS) test has gained wide acceptance as the standard by which the diagnosis of syphilis is confirmed and false-positive reactions to reagin tests

Treponemal haemagglutination test.

The introduction of the treponemal immobilization (TPI) test by Nelson and Mayer (1949) provided the first verification test for syphilis which proved fully acceptable to the clinician. After 20

The Treponema pallidum haemagglutination (TPHA) test in biological false positive and leprosy sera

TLDR
It was concluded that where reagin and TPHA tests are reactive in a person who has no history or clinical signs of syphilis, the serum should be referred for TPI and FTA-ABS testing.

Spontaneous reversion of FTA-ABS test reactions.

In a series of 56 clinically healthy persons with no history of syphilis and negative VDRL tests but reactive fluorescent treponemal antibody absorption (FTA-ABS) tests, 20 spontaneously developed

TPHA and RPL tests for yaws antibodies.

TLDR
A different group of Pacific Islanders have been screened with these treponemal tests, irrespective of reagin test results, to see if they are preferable to the reagin tests in dianostic screening or epidemiological studies.

The microhemagglutination assay for Treponema pallidum antibodies (MHA-TP), a new treponemal test for syphilis: where does it fit?

  • A. H. Rudolph
  • Biology, Medicine
    Journal of the American Venereal Disease Association
  • 1976
TLDR
The MHA-TP test seems to combine the simplicity and lower cost of nontreponemal tests and the sensitivity and specificity of treponemals tests, and thus enjoys features of both a screening and verification procedure, but additional clinical experience is needed before its role in the serologic diagnosis of syphilis can be conclusively determined.

Hemagglutination tests and related advances in serodiagnosis of syphilis.

  • R. Shore
  • Medicine, Biology
    Archives of dermatology
  • 1974
Preliminary studies indicate that hemagglutination tests for Treponema pallidum antibodies compare favorably with the fluorescent treponemal antibody absorption (FTA-ABS) test for serodiagnosis of

The laboratory diagnosis of syphilis. New concepts.

  • H. Jaffe
  • Medicine, Biology
    Annals of internal medicine
  • 1975
TLDR
The value of modified FTA tests in the diagnosis of neurosyphilis and congenital syphilis remains unproved.

Treponema pallidum haemagglutination test for syphilis. Evaluation of a modified micro-method.

  • N. Johnston
  • Biology, Medicine
    The British journal of venereal diseases
  • 1972
TLDR
An evaluation of a modified qualitative micro-TPHA technique was undertaken to assess its usefulness as a qualitative screening test for the diagnosis of treponemal infection and its overall specificity and sensitivity are thought to be comparable to those of the FTA-ABS and TPI tests.

The Treponema Pallidum Haemagglutination test as a screening procedure in the diagnosis of syphilis

TLDR
The TPHA test has proved to be more reliable than either the WR or the VDRL test, giving fewer false positive and false negative results by comparison with the FTA-ABS test.