Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations.

@article{beda2009SpecificityOS,
  title={Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations.},
  author={Carles {\'U}beda and Nicholas P. Olivarez and Peter Barry and Huaibin Wang and Xiangpeng Kong and Avery Matthews and Sandra M. Tallent and Gail E Christie and Richard P. Novick},
  journal={Molecular microbiology},
  year={2009},
  volume={72 1},
  pages={98-108}
}
SaPI1 and SaPIbov1 are chromosomal pathogenicity islands in Staphylococcus aureus that carry tst and other superantigen genes. They are induced to excise and replicate by certain phages, are efficiently encapsidated in SaPI-specific small particles composed of phage virion proteins and are transferred at very high frequencies. In this study, we have analysed three SaPI genes that are important for the phage-SaPI interaction, int (integrase) terS (phage terminase small subunit homologue) and pif… CONTINUE READING

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