Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.

  title={Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.},
  author={Oivind Hvalby and Hugh C Hemmings and Ole Paulsen and Andrew J. Czernik and Angus C. Nairn and J. M. Godfraind and Vidar Jensen and Morten Raastad and Johan F Storm and Per Oskar Andersen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 11},
Previous studies have used synthetic peptide analogs, corresponding to sequences within the pseudosubstrate domain of protein kinase C (PKC) or the autoregulatory domain of Ca2+/calmodulin-dependent protein kinase II (CaMKII), in attempts to define the contribution of each of these protein kinases to induction of long-term potentiation (LTP). However, the specificity of these inhibitor peptides is not absolute. Using intracellular delivery to rat CA1 hippocampal neurons, we have determined the… CONTINUE READING
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