Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneys.

@article{Drachenberg1997SpecificityOI,
  title={Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneys.},
  author={Cinthia B Drachenberg and Emil Steinberger and E W Hoehn-Saric and A Heffes and David K Klassen and Steven T Bartlett and John C. Papadimitriou},
  journal={Ultrastructural pathology},
  year={1997},
  volume={21 3},
  pages={227-33}
}
The pathophysiology of chronic rejection of renal allografts is poorly understood and specific morphologic markers are being sought for its diagnosis. Ultrastructural splitting and reduplication of the basal lamina of the intertubular capillaries (ITCs) have been shown to be consistently associated with transplant glomerulopathy (TG) in renal allografts and have been used as a marker of chronic allograft rejection. Although the presence of ITC abnormalities is extremely helpful diagnostically… CONTINUE READING