Specificity of expression of the muscle and brain dystrophin gene promoters in muscle and brain cells

@article{Barnea1990SpecificityOE,
  title={Specificity of expression of the muscle and brain dystrophin gene promoters in muscle and brain cells},
  author={Efrat Barnea and Dorit Zuk and Rabi Simantov and Uri Nudel and David Yaffe},
  journal={Neuron},
  year={1990},
  volume={5},
  pages={881-888}
}
The gene that is defective in Duchenne and Becker muscular dystrophies is expressed in the muscle and brain. However, the 5' ends of the 14 kb mRNA in these tissues are derived from two different exons, indicating the involvement of at least two promoters in the regulation of the cell-type and developmental specificities of expression of this gene. In the study presented here, we used the polymerase chain reaction and RNAase protection methods and various cell cultures to investigate the… CONTINUE READING
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