Specificity of effector T lymphocytes in autologous graft-versus-host disease: role of the major histocompatibility complex class II invariant chain peptide.

@article{Hess1997SpecificityOE,
  title={Specificity of effector T lymphocytes in autologous graft-versus-host disease: role of the major histocompatibility complex class II invariant chain peptide.},
  author={Ann Hess and Emilie C. Bright and Christopher Thoburn and Georgia B. Vogelsang and Richard M. Jones and M. John Kennedy},
  journal={Blood},
  year={1997},
  volume={89 6},
  pages={2203-9}
}
Administration of the immunosuppressive drug cyclosporine after autologous bone marrow transplantation induces a systemic autoimmune syndrome resembling graft-versus-host disease (GVHD). This syndrome termed autologous GVHD has significant antitumor activity. Associated with autologous GVHD is the development of T lymphocytes that recognize major histocompatibility complex (MHC) class II determinants, including self. The present studies attempted to characterize and define the molecular… CONTINUE READING
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