Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma: evaluation of the innocent bystander hypothesis.

@article{Jackson1997SpecificityOD,
  title={Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma: evaluation of the innocent bystander hypothesis.},
  author={Lisa A. Jackson and Laurie A. Campbell and Rodney A. Schmidt and Cho Chou Kuo and Alison L. Cappuccio and Myung Ja Lee and J. Thomas Grayston},
  journal={The American journal of pathology},
  year={1997},
  volume={150 5},
  pages={
          1785-90
        }
}
Chlamydia pneumoniae has been detected in atherosclerotic plaque, raising the question of whether this detection is specific to atheromatous tissue. To evaluate this question, we tested cardiovascular and non-cardiovascular tissue samples from 38 autopsy cases by polymerase chain reaction and immunocytochemistry. We also tested 33 granuloma biopsy specimens, as the organism has been detected in macrophages. C. pneumoniae was detected in coronary artery tissue from 13 (34%), lung from 5 (13… CONTINUE READING

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